A Microforce and Nanoforce Biomicroscope Device for In Vitro Mechanotransduction Investigation

Autor:	Mehdi Boukallel, Stephane Regnier, M. Girot
Rok vydání:	2008
Předmět:	Engineering Automatic control business.industry Robotics Automation Scanning probe microscopy Data acquisition Robot Artificial intelligence Electrical and Electronic Engineering Mechanotransduction business Instrumentation Biomedical engineering Haptic technology
Zdroj:	IEEE Transactions on Instrumentation and Measurement. 57:2532-2541
ISSN:	1557-9662 0018-9456
DOI:	10.1109/tim.2008.924928
Popis:	This paper deals with the development of an open design platform for explorative cell mechanotransduction investigation. The produced setup combines scanning probe microscopy (SPM) techniques and advanced robotics approaches, allowing both prolonged observations and spatial measurements on biological samples. As a result, an enhanced force probing method based on scanning microscopy techniques and advanced robotics and automation approaches is integrated in this device. Visual and force feedback control is used to achieve automatic data acquisition and monitoring processes when high skills are required. Experimentation on the mechanical cell characterization under in vitro conditions on human adherent cervix epithelial Hela cells are presented to demonstrate the viability and effectiveness of the proposed setup.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d570ad2278d288fdd6db287a3235866 https://doi.org/10.1109/tim.2008.924928 Zobrazit plný text záznamu