Antioxidant, analgesic and anti-inflammatory activities of the leafy stems of Waltheria indica L. (Sterculiaceae)
| Autor: | Marius Lompo, Innocent Pierre Guissoun, Noufou Ouedraogo, Boubacar Yaro, Mouhibatou Nadège Yougbare-Ziebrou |
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| Rok vydání: | 2016 |
| Předmět: |
Antioxidant
medicine.drug_class medicine.medical_treatment Medicine (miscellaneous) 030226 pharmacology & pharmacy 01 natural sciences Anti-inflammatory Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine In vivo medicine Pharmacology (medical) General Pharmacology Toxicology and Pharmaceutics Medicinal plants biology Traditional medicine biology.organism_classification 0104 chemical sciences Carrageenan 010404 medicinal & biomolecular chemistry chemistry Phytochemical Biochemistry Waltheria indica |
| Zdroj: | Journal of Applied Pharmaceutical Science. :124-129 |
| ISSN: | 2231-3354 |
| DOI: | 10.7324/japs.2016.60219 |
| Popis: | Aim of the study: The existence of numerous side effects following the use of anti inflammatory drugs has led to the present study about Waltheria indica (Sterculiaceae), prescribed in the treatment of many inflammatory diseases component to discover phytomedicines secondary effects mitigated. Materials and methods: The chemical principles have been demonstrated by test characterization in liquid medium according the method of Ciulei (1949). In vivo, the model of edema induced by carrageenan to cause inflammation and the model of acetic acid induced pain were used to assess the anti-inflammatory and analgesic activities of the extract. In vitro, the effects of the aqueous extract on the DPPH°°radical, the lipoxygenase and lipid peroxidation has been demonstrated. Results: Phytochemical study of leafy stems of the plant showed the presence of tannins, flavonoids, sterols, triterpenes, saponins, reducing compounds, coumarins etc. In vivo, the results showed the aqueous extract and anti- edematous effects of the analgesic of the plant. In vitro, the results revealed the aqueous extract of W. indica inhibited the radical of DPPH°°, the lipoxygenase and the lipid peroxidation. Conclusion: The presence of chemical compounds and biological properties obtained justify the contribution of the plant in traditional medicine for the treatment of diseases with inflammatory component. Keywords: Medicinal plants, Waltheriaindica L., Inflammation, Analgesia, Anti -oxidants |
| Databáze: | OpenAIRE |
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