Concentrated solar radiation as a renewable heat source for a preparative-scale and solvent-free Biginelli reaction

Autor:	Navnath T. Hatvate, Yatin U. Gadkari, Vikas N. Telvekar, Balaram S. Takale
Rok vydání:	2020
Předmět:	Solvent free Chemistry Present method Renewable heat Biginelli reaction Materials Chemistry Molecule General Chemistry Radiation Combinatorial chemistry Catalysis Efficient energy use
Zdroj:	New Journal of Chemistry. 44:8167-8170
ISSN:	1369-9261 1144-0546
DOI:	10.1039/d0nj01351j
Popis:	A well-known Biginelli reaction for the synthesis of 3,4-dihydropyrimidin-2(1H)-ones/thiones was performed in an environmentally responsible manner. Large numbers of substrates were screened, and found to give excellent yields of the desired products. In addition to the synthesis of drug molecules, the reaction was easily scaled up to 50 mmol. The present method was also energy efficient and saved more than 95% of energy when compared to conventional methods.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d40c0ff084ddb1e8c3da574fe6e734f https://doi.org/10.1039/d0nj01351j Zobrazit plný text záznamu