Pathological Changes in the Heart of the Strain CUX1 Transgenic Mice

Autor:	G Vanden Heauvel, Amanda Fletcher, D Kearn, Richard C. Baybutt, F Raza, J Buursma, Agostino Molteni, Safia Livingston, Betty Herndon
Rok vydání:	2015
Předmět:	Genetically modified mouse Karyolysis Pathology medicine.medical_specialty business.industry Kinase medicine.disease Biochemistry Fibrosis Eosinophilic Genetics medicine Vasculitis business Molecular Biology Pyknosis Biotechnology Cyclin
Zdroj:	The FASEB Journal. 29
ISSN:	1530-6860 0892-6638
Popis:	CUX1 is a transcriptional repressor gene in the network controlling G1-S phase transition. It represses the expression of the cyclin kinase (CK1) inhibitors p21 and p27. Transgenic mice constitutively expressing CUX1 develop multiorgan damage consequent to aberrant p27 expression in the kidneys (polycystic), testes (diminished spermatogenesis), and liver (fibrosis). These mice also present severe pulmonary inflammation, vasculitis, bronchiolitis, bronchiectasis, and fibrosis. This study relates to the damage induced to the heart consequent to the CUX1 expression. H&E staining of the mice hearts showed extensive myocardial inflammation, interstitial edema, hemorrhages, and increased number of macrophages neutrophils, and lymphocytes. Clusters of myocardial fibers were intensively eosinophilic with nuclear pyknosis and karyolysis suggesting the development of infarctions. A semi-quantitative evaluation of the histopathological damage made by two pathologists unaware of the slides identity, with damage grade...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d3a1770c4d115aab978ab631a854e2f https://doi.org/10.1096/fasebj.29.1_supplement.lb432 Zobrazit plný text záznamu Plný text