| Popis: |
There has recently been an increased interest in the use of hypertonic saline solutions in the fluid resuscitation of trauma victims and to control intracranial hypertension. In this study, the cerebral and haemodynamic effects of a 3.2% hypertonic saline solution were compared with those of either a 0.9% saline or 20% mannitol solution in a rabbit model of brain injury. Forty-five minutes following the creation of a left hemispheric cryogenic brain lesion, equal volumes of hypertonic saline, 0.9% saline, or mannitol were infused over a 5 minute period. Monitored variables over the ensuing 120 minutes included mean arterial pressure, central venous pressure, intracranial pressure, hematocrit, serum osmolality and oncotic pressure. Upon conclusion of the two hour study period, hemispheric water contents were determined by the wet/dry weight method. |
