Novel sulfonate analogues of combretastatin A-4
| Autor: | Kenneth J. Barr, Hovis M. Imade, Robert B. Warner, David Frost, Stephen L. Gwaltney, Jang Yun Lee, Hing L. Vernon Hills Sham, R. Bruce Credo, Peter Kovar, Jieyi Wang, Laura Gehrke, Qun Li, Nicolette A. Zielinski, Shi Chung Ng, Michael A. Nukkala |
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| Rok vydání: | 2001 |
| Předmět: |
Combretastatin A-4
Combretastatin biology Organic Chemistry Clinical Biochemistry Pharmaceutical Science macromolecular substances Prodrug Biochemistry chemistry.chemical_compound Tubulin chemistry Drug Discovery Cancer cell biology.protein Molecular Medicine Colchicine Antimitotic Agent Cytotoxicity Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 11:871-874 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(01)00098-1 |
| Popis: | Sulfonate analogues of combretastatin A-4 have been prepared. These compounds compete with colchicine and combretastatin A-4 for the colchicine binding site on tubulin and are potent inhibitors of tubulin polymerization and cell proliferation. Importantly, these compounds also inhibit the proliferation of P-glycoprotein positive (+) cancer cells, which are resistant to many other antitumor agents. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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