ChemInform Abstract: Reaction of 5-Substituted Tetrazoles with Trifluoroacetic Anhydride

Autor:	F. A. Pokatilov, V. N. Kizhnyaev, S. K. Strunevich, O. N. Verkhozina, A. G. Proidakov, L. I. Vereshchagin
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Acylation chemistry.chemical_compound chemistry Carboxylic acid Polymer chemistry Tetrazole General Medicine Trifluoroacetic anhydride Ring (chemistry)
Zdroj:	ChemInform. 39
ISSN:	1522-2667 0931-7597
DOI:	10.1002/chin.200816142
Popis:	5-Substituted tetrazoles readily react with trifluoroacetic anhydride at 20–25°C to give the corresponding 2-substituted 5-trifluoromethyl-1,3,4-oxadiazoles, in contrast to published data according to which the title compounds are converted into 1,3,4-oxadiazole derivatives on heating with carboxylic acid anhydrides or chlorides at 100–120°C. The reaction is governed not only by the rate of acylation of the tetrazole ring and temperature conditions but also by the stability of intermediate N-acyltetrazoles.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d23238d99bbd7cedcbb8801cdb6dece https://doi.org/10.1002/chin.200816142 Zobrazit plný text záznamu Plný text