Cancer of the tonsil: Improved survival with combination therapy
| Autor: | Kumar S. Dasmahapatra, Benjamin F. Rush, Mirseyed Ali Mohit-Tabatabai, Maimu Ohanian, Martin Feuerman, George J. Hill |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Gynecology
Cancer Research Chemotherapy medicine.medical_specialty Combination therapy business.industry medicine.medical_treatment Cancer medicine.disease Bleomycin Gastroenterology Radiation therapy chemistry.chemical_compound medicine.anatomical_structure Oncology chemistry Internal medicine Tonsil medicine Methotrexate Stage (cooking) business medicine.drug |
| Zdroj: | Cancer. 57:451-455 |
| ISSN: | 1097-0142 0008-543X |
| DOI: | 10.1002/1097-0142(19860201)57:3<451::aid-cncr2820570308>3.0.co;2-l |
| Popis: | One hundred seventy-four cases of squamous cell cancer of the tonsil (SCCT) were reviewed. Radiation therapy (RT) alone was used in 81 patients, surgery alone (S) in 19 patients, preoperative RT + S in 49 patients, and chemotherapy [( C] methotrexate plus bleomycin plus cisplatin) in 25 patients. The 5-year survival was 83% in Stage I (n = 21), 72% in Stage II (n = 19), 23% in Stage III (n = 34), and 15% in Stage IV (n = 100). RT and S were equally effective in Stages I and II. In Stage III, the 5-year survival for RT + S was 31% versus 11% for RT alone; and in Stage IV, the respective 3- and 5-year survivals for RT + S were 24% and 15% versus 6% and 0%, respectively, for RT alone. There was an 84% response rate to C, and the patients who completed C + RT + S had 3- and 5-year survival rates of 41.7% and 32%, respectively. Our results indicate that RT + S appears to offer better survival in Stage III and IV SCCT. The high response rate in early survival data seen with C + RT + S suggests a promising role for this approach. |
| Databáze: | OpenAIRE |
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