New synthesis of a selective estrogen receptor modulator using an enatioselective phosphine-mediated 2+3 cycloaddition

Autor:	Debra J. Wallace, Robert A. Reamer
Rok vydání:	2013
Předmět:	Chemistry Stereochemistry Organic Chemistry Enantioselective synthesis Biochemistry Cycloaddition Catalysis chemistry.chemical_compound Selective estrogen receptor modulator Drug Discovery Robinson annulation Enone Phosphine Octane
Zdroj:	Tetrahedron Letters. 54:4425-4428
ISSN:	0040-4039
DOI:	10.1016/j.tetlet.2013.06.023
Popis:	A new synthetic approach to the selective estrogen agonist 1 is described. The key steps in the route are a phosphine catalyzed 2+3 cycloaddition between an indanone enone and allenyl methyl ketone, and an unusual Robinson annulation to afford a bicylco[3.2.1]octane. The potential benefits of the new route are discussed along with efforts to render the approach asymmetric.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d190bc1bb05d532ddcbd0a65c2aac6e https://doi.org/10.1016/j.tetlet.2013.06.023 Zobrazit plný text záznamu Full Text from ScienceDirect