Pseudotheonamides, Serine Protease Inhibitors from the Marine Sponge Theonella swinhoei1
| Autor: | Shigeki Matsunaga, Akito Masuda, Youichi Nakao, Nobuhiro Fusetani |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Serine protease
Tetrapeptide biology Stereochemistry Chemistry Cyclotheonamide A Serine Protease Inhibitors General Chemistry Theonella swinhoei Ring (chemistry) biology.organism_classification Biochemistry Combinatorial chemistry Catalysis Sponge Colloid and Surface Chemistry biology.protein Tyrosine |
| Zdroj: | Journal of the American Chemical Society. 121:2425-2431 |
| ISSN: | 1520-5126 0002-7863 |
| DOI: | 10.1021/ja9831195 |
| Popis: | Six new peptides with serine protease inhibitory activity have been isolated from the marine sponge Theonella swinhoei. Their structures including absolute stereochemistry were unambiguously established by interpretation of spectral data and chemical degradation. Pseudotheonamides A1 (1), A2 (2), and B2 (3) are linear pentapeptides embracing the rare piperazinone and piperidinoiminoimidazolone ring systems. Pseudotheonamide C (4) contains v-Tyr (vinylogous tyrosine) instead of a piperazinone ring. Pseudotheonamide D (5) is a tetrapeptide which lacks a C-terminal k-Arg (α-ketohomoarginine) unit. Dihydrocyclotheonamide A (6) is a reduction product of the known cyclotheonamide A (7).2 |
| Databáze: | OpenAIRE |
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