| Autor: |
Fahimeh Rezazadeh, Nima Fassihi, Dorsa Mahdavi, Amir Tabesh, Elham Tayebi Khorami, hossein sedarat |
| Rok vydání: |
2022 |
| Předmět: |
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| DOI: |
10.21203/rs.3.rs-1552798/v1 |
| Popis: |
Introduction: Temporomandibular joint disorders (TMD) are characterized by jaw pain combined with dysfunction of the muscles and joints. Extreme fabrication of oxidative stress in the TMJ thus results in tissue injury, which advances to TMD.The aim of this study was to evaluate the Glutathion reductase, catalase, and free thiol in saliva of TMD patients and compare it with people without TMD. Materials and Methods In this cross sectional study 35 patients with temporomandibular joint and 20 people without TMD were participated in the study. Five mL of each unstimulated saliva sample was collected in the morning and salivary level of antioxidants was assessed by ELISA (Enzyme Linked Immunosorbent Assay) technique. Helkimo index and visual analogue scale (VAS) also were measured during this experiment. Results There was significantly decrease in salivary level of Glutathion reductase and catalase in patients but there were no differences among two groups in free-thiol level.There was also correlation between antioxidant status and presence of click, pain and severity of disease; however, there was no correlation between age and gender with antioxidants contents. Conclusion The mean salivary levels of Glutathion reductase and Catalase in TMD patients were lower than that in the control group, which means these antioxidants were affected by TMD and also related with severity of it, but no significant difference was detected in salivary Free thiol between groups. So salivary Glutathion reductase and Catalase level may be used as a biomarker for TMD monitoring and treatment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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