Total synthesis of 1α,25,28-trihydroxyergocalciferol
| Autor: | John Sereno, Andrew D. Batcho, Ronald L. Horst, Milan R. Uskokovic, Enrico G. Baggiolini, Bernard Michael Hennessy |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
chemistry.chemical_classification
Bicyclic molecule Chemistry Stereochemistry medicine.medical_treatment Organic Chemistry Clinical Biochemistry Synthon Pharmaceutical Science Total synthesis Ring (chemistry) Biochemistry Cycloaddition Steroid Nitrone Drug Discovery medicine Molecular Medicine Aliphatic compound Molecular Biology |
| Zdroj: | Bioorganic & Medicinal Chemistry Letters. 3:1821-1824 |
| ISSN: | 0960-894X |
| DOI: | 10.1016/s0960-894x(00)80112-2 |
| Popis: | A convergent total synthesis of 1α,25,28-trihydroxyergocalciferol (1), using an available A ring synthon and a CD synthon which was prepared via a thermodynamically controlled dipolar cycloaddition of methyl 3,3-dimethylacrylate and a C-23 nitrone followed by subsequent removal of the nitrogen function, is described. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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