Sultam Thioureas: Synthesis and Antiviral Activity Against West Nile Virus

Autor:	Jason R. McGuire, Joseph W. Parks, Warren J. L. Wood, Joanna R. Farrell, Rachel M. Feeny, Edward J. Valente, Albert C. Abbene, Elaina B. Graham, Mark G. Epstein, Robert W. Zoellner, Joseph V. Pagano, Eric Barklis, Diane N. Le
Rok vydání:	2011
Předmět:	biology West Nile virus Stereochemistry Organic Chemistry biology.organism_classification medicine.disease_cause Chemical synthesis Virus Flaviviridae Flavivirus chemistry.chemical_compound Thiourea chemistry medicine
Zdroj:	Synlett. 2012:301-305
ISSN:	1437-2096 0936-5214
DOI:	10.1055/s-0031-1290124
Popis:	The syntheses of eleven sultam thioureas, including nine new compounds, are described. These compounds were synthesized from thioureas and include the first sultam thioureas in which the two thiourea nitrogen groups are not identical. In addition, the first X-ray crystal structures of sultam thioureas and the antiviral activity of these compounds against West Nile virus (WNV) are reported.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d11ebce48a467306033c146be8a331b https://doi.org/10.1055/s-0031-1290124 Zobrazit plný text záznamu