Molecular Modelling of the Antagonist Binding Site on the Adenosine A, Receptor
Autor: | W. Soudijn, P. Nissen, I. Van Wijngaarden, Th. H. W. Van Vlijmen, P. J. M. Van Galen, A. P. Ljzerman |
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Rok vydání: | 1991 |
Předmět: | |
Zdroj: | Nucleosides and Nucleotides. 10:1039-1047 |
ISSN: | 0732-8311 |
Popis: | With the aid of molecular modelling both adenosine and adenosine A, receptor antagonists belonging to various chemical classes were compared. A model for the antagonist binding site was developed. As a consequence 1H-imidazo[4, 5-c]-quinolin-4-amines were synthesized, constituting a novel class of potent non-xanthine adenosine receptor antagonists. |
Databáze: | OpenAIRE |
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