Molecular Modelling of the Antagonist Binding Site on the Adenosine A, Receptor

Autor:	W. Soudijn, P. Nissen, I. Van Wijngaarden, Th. H. W. Van Vlijmen, P. J. M. Van Galen, A. P. Ljzerman
Rok vydání:	1991
Předmět:	Chemistry Antagonist Biochemistry Adenosine receptor Adenosine Adenosine a Genetics medicine Enzyme-linked receptor Binding site Receptor Adenosine A2B receptor medicine.drug
Zdroj:	Nucleosides and Nucleotides. 10:1039-1047
ISSN:	0732-8311
Popis:	With the aid of molecular modelling both adenosine and adenosine A, receptor antagonists belonging to various chemical classes were compared. A model for the antagonist binding site was developed. As a consequence 1H-imidazo[4, 5-c]-quinolin-4-amines were synthesized, constituting a novel class of potent non-xanthine adenosine receptor antagonists.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6d0df16e2180d17edc16b16448f9b603 https://doi.org/10.1080/07328319108047241 Zobrazit plný text záznamu