Design, structural and spectroscopic elucidation, and the in vitro biological activities of new triorganotin dithiocarbamates – Part II
| Autor: | G.M. de Lima, Carlos B. Pinheiro, Eucler B. Paniago, Isabella P. Ferreira, José D. Ardisson, Willian R. Rocha, Jacqueline A. Takahashi |
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| Rok vydání: | 2014 |
| Předmět: |
chemistry.chemical_classification
biology Chemistry Aspergillus niger Biological activity Aspergillus flavus Carbon-13 NMR biology.organism_classification Medicinal chemistry Aspergillus parasiticus Inorganic Chemistry chemistry.chemical_compound Mössbauer spectroscopy Materials Chemistry Penicillium citrinum Physical and Theoretical Chemistry Dithiocarbamate |
| Zdroj: | Polyhedron. 79:161-169 |
| ISSN: | 0277-5387 |
| DOI: | 10.1016/j.poly.2014.05.001 |
| Popis: | The two novel dithiocarbamate salts, [Na{S2CNR(R1)}] (i), [Na{S2CNR(R2)}] (ii), R = methyl, R1 = CH2CH(OMe)2, R2 = 2-methyl-1,3-dioxolane, previously synthesized by us, have been used in chemical reactions with triorganotin halides. Hence, five new complexes: [SnPh3{S2CNR(R1)}] (1), [SnCy3{S2CNR(R1)}] (2), [SnMe3{S2CNR(R2)}] (3), [SnPh3{S2CNR(R2)}] (4) and [SnCy3{S2CNR(R2)}] (5), [R = methyl, R1 = CH2CH(OMe)2, and R2 = 2-methyl-1,3-dioxolane], have been isolated. All compounds were authenticated in terms of infrared, 1H and 13C NMR, and the complexes were also characterized using 119Sn NMR, 119Sn Mossbauer and X-ray crystallography, in the case of complexes (1), (4) and (5). The biological activity of all derivatives has been screened in terms of IC90 (μmol L−1) and IC50 (μmol L−1) against Aspergillus flavus, Aspergillus niger, Aspergillus parasiticus and Penicillium citrinum, and the results correlated well with a performed study of structure–activity relationship (SAR). Complexes (1) and (4) displayed nanomolar inhibition concentration in terms of IC50. |
| Databáze: | OpenAIRE |
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