Practical synthesis of α-amino acids using cis-aminoindanol derived hippuric acid amide as a glycine enolate equivalent

Autor:	Ralph P. Volante, Choi Woo-Baeg, Jaemoon Lee, Paul J. Reider, Joseph E. Lynch
Rok vydání:	1998
Předmět:	chemistry.chemical_classification Chiral auxiliary Organic Chemistry Enantioselective synthesis Hippuric acid Alkylation Biochemistry Medicinal chemistry Amino acid chemistry.chemical_compound chemistry Amide Drug Discovery Glycine Lithium chloride lipids (amino acids peptides and proteins)
Zdroj:	Tetrahedron Letters. 39:3679-3682
ISSN:	0040-4039
DOI:	10.1016/s0040-4039(98)00636-4
Popis:	The use of cis -aminoindanol as a chiral auxiliary for asymmetric synthesis of α-amino acids is described. Alkylation of the chirally modified glycine enolate 2 with a number of alkyl halides in the presence of lithium chloride gave the corresponding alkylated product in 90 ∼ 99% diastereoselectivity.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6cdb618b19e3c3a6f44532de01fb2dab https://doi.org/10.1016/s0040-4039(98)00636-4 Zobrazit plný text záznamu Full Text from ScienceDirect