Progressive Multifocal Leukoencephalopathy in Renal Transplant Recipients
| Autor: | William F. McCormick, Harry E. Sarles, Sydney S. Schochet, John R. Calverley |
|---|---|
| Rok vydání: | 1976 |
| Předmět: |
Pathology
medicine.medical_specialty business.industry Parkinsonism Progressive multifocal leukoencephalopathy medicine.medical_treatment Central nervous system Immunosuppression medicine.disease Lymphoma Transplantation Leukemia medicine.anatomical_structure Renal transplant Internal Medicine medicine business |
| Zdroj: | Archives of Internal Medicine. 136:829 |
| ISSN: | 0003-9926 |
| DOI: | 10.1001/archinte.1976.03630070067020 |
| Popis: | Progressive multifocal leukoencephalopathy (PML), a slowly progressive papovavirus infection of the central nervous system (CNS), has been reported in more than 110 patients to date, over half of whom have had either leukemia or lymphoma. 1-13 Only occasionally has no obvious underlying immune-altering disorder been noted. 1,2 To our knowledge, only three patients have been reported previously to have developed PML after long-term immunosuppression for renal transplantation 5,12,13 ; the patient discussed here is the fourth. Our patient also demonstrated unilateral parkinsonian signs attributable to involvement of the extrapyramidal motor system. Parkinsonism has been a very unusual clinical manifestation of PML, and has been reported previously in only one patient. 14 We believe that PML is emerging as a potentially serious problem in renal transplant recipients. PATIENT SUMMARY A 34-year-old man who had had multiple admissions for chronic renal failure and hypertension caused by chronic proliferative glomerulonephritis had both kidneys (and |
| Databáze: | OpenAIRE |
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