A method for the synthesis of hydroxamic acids on solid phase

Autor:	Christopher David Floyd, Sanjay R. Patel, Mark Whittaker, Christopher Lewis
Rok vydání:	1996
Předmět:	Hydroxamic acid Chemistry Organic Chemistry technology industry and agriculture Tripeptide Cleavage (embryo) Biochemistry Combinatorial chemistry Adduct chemistry.chemical_compound Wang resin stomatognathic system Phase (matter) Drug Discovery Mitsunobu reaction
Zdroj:	Tetrahedron Letters. 37:8045-8048
ISSN:	0040-4039
DOI:	10.1016/0040-4039(96)01821-7
Popis:	Wang resin 1 was modified using a Mitsunobu reaction to give resin bound O-hydroxylamine 3. This resin was acylated and the adduct cleaved from the resin as a hydroxamic acid on treatment with TFA. Series of tripeptide, and sulfonamido 9 hydroxamic acids which act as inhibitors of metalloproteinases have been prepared. Resins more sensitive to acid cleavage can also be modified to simplify the work-up procedure.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6cc5790460d6a4dbbf24fba15b3de2dd https://doi.org/10.1016/0040-4039(96)01821-7 Zobrazit plný text záznamu Full Text from ScienceDirect