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This study was designed to provide a rapid highly protective passive immunization of chickens against necrotic enteritis(NE). This aim was established by preparation of NE alpha toxin IgY in chicken egg yolk, such preparation was found tohave specific anti NE alpha toxin titer 40 I.U by SNT and 0.237 optical density (OD) by ELISA. It was found that oraladministration of 40, 20, 10 and 5 IU/ml of IgY / poult after experimental infection with Clostridium perfringens typeA, resulted in protective rates of 96%, 88%, 80% and 60% respectively. Chickens' sera of passively immunized birdsshowed antibody titers of 1, 2 and 1.5 I U in the first, second and third days’ post immunization respectively. It wasconcluded that IgY for NE alpha toxin type A could be used successfully to protect or even minimize the severity of thedisease during possible outbreaks |
