How polymorphisms of the cytochrome P450 genes affect ibuprofen and diclofenac metabolism and toxicity / Kako polimorfizmi gena citokroma P450 utječu na metabolizam i toksičnost ibuprofena i diklofenaka
| Autor: | Valon Krasniqi, Nada Božina, Iva Klarica Domjanović, Aleksandar Dimovski, Ivan Bilić |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
business.industry organic chemicals Public Health Environmental and Occupational Health Pharmacology Toxicology Ibuprofen 03 medical and health sciences 030104 developmental biology Diclofenac Pharmacokinetics Anesthesia Pharmacogenomics Medicine business Adverse effect CYP2C9 Pharmacogenetics Drug metabolism medicine.drug |
| Zdroj: | Archives of Industrial Hygiene and Toxicology. 67:1-8 |
| ISSN: | 0004-1254 |
| DOI: | 10.1515/aiht-2016-67-2754 |
| Popis: | Interindividual variability in drug metabolism is an important cause of adverse drug reactions and variability in drug efficiency. Polymorphisms of cytochrome P450 (CYPs) genes have a significant effect on drug metabolism and toxicity. This review brings an update about how genetic polymorphisms of CYP2C8 and CYP2C9 enzymes affect the disposition and clinical outcomes of ibuprofen and diclofenac, two of the most common pain relievers. The most common side effects associated with the influence of CYP2C8*3 and CYP2C9*2*3 variants on ibuprofen and diclofenac pharmacokinetics are hepatotoxicity and gastrointestinal bleeding. CYP genotyping may therefore identify patients at increased risk of these adverse reactions, and these patients could have their doses adjusted or start receiving another NSAID that does not share the same metabolic pathways with ibuprofen or diclofenac. However, before genotyping is introduced into regular clinical practice, more research is needed to evaluate the effectiveness of this strategy in improving treatment with ibuprofen and diclofenac. |
| Databáze: | OpenAIRE |
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