Treatment With Statin on Atheroma Regression Evaluated by Intravascular Ultrasound With Virtual Histology (TRUTH Study) Rationale and Design
| Autor: | Tsuyoshi Nozue, Shingo Yamamoto, Shinichi Tohyama, Shigeo Umezawa, Tomoyuki Kunishima, Akira Sato, Shogo Miyake, Youichi Takeyama, Yoshihiro Morino, Takao Yamauchi, Toshiya Muramatsu, Kiyoshi Hibi, Takashi Sozu, Ichiro Michishita, null Kanagawa PTCA Conference Study Group |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Statin medicine.diagnostic_test medicine.drug_class Unstable angina business.industry medicine.medical_treatment Percutaneous coronary intervention General Medicine medicine.disease Coronary artery disease Atheroma Internal medicine Intravascular ultrasound medicine Cardiology cardiovascular diseases Radiology Cardiology and Cardiovascular Medicine Prospective cohort study business Pravastatin medicine.drug |
| Zdroj: | Circulation Journal. 73:352-355 |
| ISSN: | 1347-4820 1346-9843 |
| DOI: | 10.1253/circj.cj-08-0593 |
| Popis: | Background Many clinical trials have shown that 3-hydroxy-3-methylglutaryl-conenzyme A reductase inhibitors (statins) can significantly reduce the incidence of coronary artery disease in both primary and secondary prevention. A recent study showed that aggressive lipid-lowering therapy with statins could achieve regression of coronary artery plaque evaluated with gray-scale intravascular ultrasound (IVUS). However, the actual changes in coronary artery plaque composition produced by statin therapy have not been well delineated. Methods and Results This study will be a prospective, open-label, randomized multicenter study of 160 patients with stable or unstable angina who have undergone percutaneous coronary intervention with Virtual HistologyTM IVUS (VH-IVUS). Patients will be randomly assigned to either the pitavastatin or pravastatin group. After treatment for 24-40 weeks, VH-IVUS will be performed again in the same segment of the coronary artery. The primary endpoint will be quantitative changes in each of the 4 components measured by VH-IVUS. Conclusion The treatment with statin on atheroma regression evaluated by intravascular ultrasound with Virtual Histology (TRUTH) study will be the first multicenter study using VH-IVUS to evaluate the effects of statins on changes in coronary artery plaque composition and the findings will clarify the mechanisms of coronary artery plaque stabilization. (Circ J 2009; 73: 352 - 355) |
| Databáze: | OpenAIRE |
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