One-Step Synthesis of Thieno[2,3-d]pyrimidin-4(3H)-ones via a Catalytic Four-Component Reaction of Ketones, Ethyl Cyanoacetate, S8, and Formamide
| Autor: | Taoda Shi, Lynn Kaneko, Ryan Busse, Eli Chapman, Mae Zhang, Jason M. Machulis, Donna D. Zhang, Damian J. Mason, Michael Sandino, Andrew J. Ambrose |
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| Rok vydání: | 2018 |
| Předmět: |
Green chemistry
Formamide Four component Renewable Energy Sustainability and the Environment General Chemical Engineering One-Step 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Combinatorial chemistry 0104 chemical sciences Catalysis chemistry.chemical_compound chemistry Ethyl cyanoacetate Multi-component reaction Environmental Chemistry Pharmacophore 0210 nano-technology |
| Zdroj: | ACS Sustainable Chemistry & Engineering. 7:1524-1528 |
| ISSN: | 2168-0485 |
| DOI: | 10.1021/acssuschemeng.8b05276 |
| Popis: | Thieno[2,3-d]pyrimidin-4(3H)-ones are important pharmacophores that have previously required a three-step synthesis with two chromatography steps. We herein report a green approach to the synthesis... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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