Increased oesophageal acid exposure at the beginning of the recumbent period is primarily a recumbent-awake phenomenon

Autor: Choo Hean Poh, Nicole Ashpole, Larissa M. Allen, Tomas Navarro-Rodriguez, H. Cui, Marcia R. Willis, Ronnie Fass, Stuart F. Quan, Bridget Moty, Isaac Malagon, Jeannette Powers, Anita Gasiorowska
Rok vydání: 2010
Předmět:
Zdroj: Alimentary Pharmacology & Therapeutics. 32:787-794
ISSN: 0269-2813
DOI: 10.1111/j.1365-2036.2010.04403.x
Popis: Summary Background A significant increase in oesophageal acid exposure during early recumbent period has been demonstrated. Aim To determine if acid reflux during the early recumbent period occurs in the recumbent-asleep or recumbent-awake period using a novel integrative actigraphy and pH programme. Method Thirty-nine subjects with heartburn at least three times a week were included. Subjects underwent pH testing concomitantly with actigraphy. Simultaneously recorded actigraphy and pH data were incorporated using a novel integrative technique to determine sleep and awake periods. Characteristics of acid reflux were compared between the recumbent-awake and recumbent-asleep periods. Results Seventeen (44.7%) subjects had acid reflux events during recumbent-awake period as compared to seven (18.4%) in the corresponding recumbent-asleep period (P = 0.046). The mean number of acid reflux events in recumbent-awake period was significantly higher than in the corresponding recumbent-asleep period (8.1 ± 4.4 vs. 3.2 ± 1.5, P
Databáze: OpenAIRE
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