Antimycobacterial cycloartane derivatives from the roots of Trichilia welwistchii C. DC (Meliaceae)
| Autor: | Moses K. Langat, Pierre Mkounga, Alain François Kamdem Waffo, Armelle Tontsa Tsamo, Augustin Ephrem Nkengfack, Edwige P. Fodja Saah |
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| Rok vydání: | 2021 |
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| Zdroj: | Zeitschrift für Naturforschung B. 76:475-480 |
| ISSN: | 1865-7117 0932-0776 |
| DOI: | 10.1515/znb-2021-0060 |
| Popis: | Chemical investigation of the roots of Trichilia welwitschii yielded a cycloartane type terpenoid 28,29-bis-norcycloart-24-en-3β,4α,6α-triol (1), isolated as pure compound for the first time, three coumarins and three sterols. New cycloartane derivatives (1a) and (1b+1c) were obtained by hemi-synthetic reaction of compound 1. The structures of 1a–c were established by spectroscopic methods including 1D and 2D-NMR analysis, HR-EIMS, chemical transformations and by comparison of these data with those of related compounds. Evaluated for their antimycobacterial potential, compound 1 and 1b+1c were determined to show significant activities against Mycobacterium tuberculosis MIC values of 6.25 μg mL−1 while compound 1a displayed weak activity showing MIC > 100 μg mL−1. Compounds 2–4 displayed moderate activity with MIC values range from 12.5 to 50 μg mL−1. |
| Databáze: | OpenAIRE |
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