EFFECT OF CHOLERA TOXIN ON Na TRANSPORT IN INTESTINE

Autor:	H Lestradet, Jehan-F. Desjeux, Peter F. Curran, Yuan-Heng Tai
Rok vydání:	1974
Předmět:	medicine.medical_specialty Cholera toxin Ileum Biology medicine.disease_cause medicine.disease digestive system Cholera In vitro Endocrinology medicine.anatomical_structure Internal medicine Pediatrics Perinatology and Child Health medicine Secretion Transcellular Na absorption
Zdroj:	Pediatric Research. 8:909-909
ISSN:	1530-0447 0031-3998
DOI:	10.1203/00006450-197411000-00071
Popis:	Massive secretion of fluid and electrolytes into the intestinal lumen is observed in cholera. This study was, therefore, undertaken to determine the role of the epithelial cells in the Na secretion observed in cholera. From measurements of flux as a function of electrical potential, the transcellular Na fluxes (Jc) were estimated, in vitro, on ileum treated with cholera toxin (CT) for 60 minutes and compared with Jc from unchallenged control (C) intestine from the same rabbit. In absence of electrochemical potential, in Ringer's solution, CT caused a net Na secretion (−1.35 + 0.21 μeq/hr cm2), without statistical change in short circuit current. The net secretion appears to be due to a decrease of transcellular Na flux from mucosa to serosa (Jcms) (−0.94 ± 0.35 μeq/hr cm2) and an increase of cellular flux from serosa to mucosa (Jcsm) (+0.75 ± 0.64 μeq/hr cm2). The addition of 10mM glucose caused an increase (p
Databáze:	OpenAIRE
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