Cardiac Glycoside Toxicity
Autor: | Salmaan Kanji, Robert MacLean |
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Rok vydání: | 2012 |
Předmět: |
medicine.medical_specialty
education.field_of_study Hyperkalemia business.industry medicine.medical_treatment Population General Medicine Critical Care and Intensive Care Medicine medicine.disease Gastroenterology Toxicology Internal medicine Toxicity medicine Plasmapheresis medicine.symptom education business Chronic toxicity Toxidrome Digitalis Toxicity Cardiac glycoside medicine.drug |
Zdroj: | Critical Care Clinics. 28:527-535 |
ISSN: | 0749-0704 |
Popis: | Digitalis toxicity produces a toxidrome characterized by gastrointestinal, neurologic, electrolyte, and nonspecific cardiac manifestations. Chronic toxicity remains much more difficult to recognize compared with an acute presentation because of the nonspecific manifestations; therefore, serum glycoside levels are essential for diagnosis in this population. The mainstay of management continues to be rapid toxidrome identification followed by digoxin-specific antibody fragment therapy with supportive care. Several controversies still remain, including therapy for patients dependent on hemodialysis, appropriateness of calcium therapy for hyperkalemia, ideal agents for arrhythmia therapy, and the potential utility of plasmapheresis for removal of bound digoxin-antibody fragment complexes. |
Databáze: | OpenAIRE |
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