| Autor: |
Lewis Myles E, Nicole Driggins S, William Y. Boadi, Venkataswarup Tiriveedhi, Jawaher Albaqami |
| Rok vydání: |
2018 |
| Předmět: |
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| Zdroj: |
MOJ Bioequivalence & Bioavailability. 5 |
| ISSN: |
2573-2951 |
| Popis: |
Background One significant cause of mortality and morbidity among populations around the globe is cancer Many plants have shown their ability for use in developing anti cancer drugs Approximately of all anti cancer drugs recently in use are a compound derived from plants Several studies have shown that extracted plants are capable of inducing apoptosis reducing the lipid peroxides in various cancer cells Herein we examined the underlying mechanism of Onosma bracteatum cytotoxicity in prostate cancer PC lung cancer A and breast cancer BT Methods In this study O bracteatum leaves in methanol extract was prepared and exposed to a human breast prostate and lung cancer cells Lipid peroxidation and Elisa assays were used to assess the cytotoxic effect of the O bracteatum on BT PC and A cancer cells Result We found that O bracteatum with multiple concentrations and g ml reduced cell viability in a dose and time dependent method The results from lipid peroxides assay indicate that the lipid peroxides MDA were decreased in prostate breast and lung cancer cells in concentration g ml compared with the control group Furthermore Elisa assay also revealed that caspase activated in prostate breast and lung cancer cells in concentration g ml compared to the control DMSO Conclusion O bracteatum has potential as a drug candidate for the treatment of prostate cancer lung cancer and breast cancer |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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