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Introduction: - Corona virus disease (COVID-19) is an emerging disease that threatens the biosecurity of all countries and spreading rapidly worldwide. Early diagnosis of the disease is essential because of high infectivity and mortality rates of COVID-19. Aims and objective: -The study was to observe and compare the clinical, biochemical and hematological proles between high dependency unit (HDU), Intensive care unit (ICU) and pregnant women with conrmed COVID 19 positive RT-PCR. Material and methods: - This study is conducted in COVID-19 dedicated Tertiary Care Hospital attached to RNT Medical College, Udaipur of Southern Rajasthan. Data of all patients with conrmed positive RT-PCR was collected during April 26, 2021 to May 31, 2021 from respective Lab Coordinator appointed for this purpose. SPSS statistics software was used for data statistics and mapping. Continuous variables were expressed as median and IQR (Inter Quarentile Range). Results:- Out of 428 patients 174 patients were in ICU, 235patients were in HDU and 19 patients were pregnant women. Mean age of 428 is 47.32 year ranging 18-86yrs. Among these 428 patients 267(62.38%) patients were males and 161(37.62%) patients were females. The biochemical, coagulation and hematological parameters such as Serum Ferritin, Lactate Dehydrogenase, C-Reactive Protein, Blood Sugar, D-Dimer, Prothrombin Time & INR, ESR, WBC, and Absolute Neutrophil Count were statistically signicant(p |