Synthesis, characterization, and antimicrobial activity of novel substituted 2H-chromenyl acrylates
| Autor: | D. Cherupally, M. Ravi, E. V. Reddy, H. Bee, N. J. P. Subhashini, B. China Raju |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Antifungal
chemistry.chemical_classification Acrylate 010405 organic chemistry medicine.drug_class General Chemistry 010402 general chemistry Antimicrobial 01 natural sciences 0104 chemical sciences chemistry.chemical_compound chemistry Ylide medicine Proton NMR Organic chemistry Spectral data Dichloromethane Gram |
| Zdroj: | Russian Journal of General Chemistry. 86:2900-2905 |
| ISSN: | 1608-3350 1070-3632 |
| DOI: | 10.1134/s1070363216120586 |
| Popis: | The present study deals with conventional Witting olefination of 2H-chromene-3-carbaldehydes with stabilized ylide in the presence of dichloromethane to afford (2E)-ethyl-3-(4-chloro-2H-chromen-3-yl) acrylate derivatives. All the products were found to have E-geometry at C=C bond. The synthesized compounds were characterized by spectral data such as IR, 1H NMR and MS. Compounds were screened for antimicrobial activity against strains of gram positive, gram negative bacterial and fungal strains. All compounds showed good antibacterial and antifungal activity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|