Spongistatin synthetic studies. 2. Assembly of the C(18–28) spiroketal

Autor:	Christopher S. Brook, Qiyan Lin, Armen M. Boldi, Linghang Zhuang, Amos B. Smith, Robert E. Lee Trout, William H. Moser
Rok vydání:	1997
Předmět:	Antitumor activity chemistry.chemical_compound chemistry Protein subunit Organic Chemistry Drug Discovery Spongistatin Biochemistry Combinatorial chemistry Dithiane Sequence (medicine)
Zdroj:	Tetrahedron Letters. 38:8671-8674
ISSN:	0040-4039
Popis:	The C(18–28) CD-ring spiroketal subunit of the spongistatins, marine polyether macrolides with unprecedented antitumor activity, has been generated via a highly convergent and completely stereocontrolled sequence. Key operations include a one-flask dithiane bisalkylation and a metal-assisted spiroketal equilibration.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6c7f126a3a7fe59f8b39066b0e9131a6 https://doi.org/10.1016/s0040-4039(97)10500-7 Zobrazit plný text záznamu Full Text from ScienceDirect