Spongistatin synthetic studies. 2. Assembly of the C(18–28) spiroketal
Autor: | Christopher S. Brook, Qiyan Lin, Armen M. Boldi, Linghang Zhuang, Amos B. Smith, Robert E. Lee Trout, William H. Moser |
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Rok vydání: | 1997 |
Předmět: | |
Zdroj: | Tetrahedron Letters. 38:8671-8674 |
ISSN: | 0040-4039 |
Popis: | The C(18–28) CD-ring spiroketal subunit of the spongistatins, marine polyether macrolides with unprecedented antitumor activity, has been generated via a highly convergent and completely stereocontrolled sequence. Key operations include a one-flask dithiane bisalkylation and a metal-assisted spiroketal equilibration. |
Databáze: | OpenAIRE |
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