Maternal exposure to radiographic exams and major structural birth defects
| Autor: | Robert J. Emery, Hyeyeun Lim, A. J. Agopian, Dorothy Kim Waller, Lawrence W. Whitehead, Charles W. Beasley, Peter H. Langlois |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Gynecology
Embryology medicine.medical_specialty Pregnancy Obstetrics business.industry Urinary system Retrospective cohort study General Medicine Odds ratio medicine.disease Confidence interval 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure Great arteries 030220 oncology & carcinogenesis Pediatrics Perinatology and Child Health medicine Abdomen business Pelvis Developmental Biology |
| Zdroj: | Birth Defects Research Part A: Clinical and Molecular Teratology. 106:563-572 |
| ISSN: | 1542-0752 |
| DOI: | 10.1002/bdra.23496 |
| Popis: | Background An increasing number of radiologic exams are performed in the United States, but very few studies have examined the effects of maternal exposure to radiologic exams during the periconceptional period and birth defects. Objectives To assess the association between maternal exposure to radiologic exams during the periconceptional period and 19 categories of birth defects using a large population-based study of birth defects. Methods We studied 27,809 case mothers and 10,200 control mothers who participated in the National Birth Defects Prevention Study and delivered between 1997 and 2009. Maternal exposure to radiologic exams that delivered ionizing radiation to the urinary tract, lumbar spine, abdomen, or pelvis were identified based on the mother's report of type of radiologic exams, organ or body part scanned and the month during which the exam occurred Results Overall, 0.9% of mothers reported exposure to one of these types of radiographic exams during the periconceptional period. We observed significant associations between maternal exposure during the first trimester and isolated Dandy-Walker malformation (odds ratio = 7.7; 95% confidence interval, 1.8–33) and isolated d-transposition of the great arteries (odds ratio = 3.8; 95% confidence interval, 1.4–10.3). However, the result for isolated Dandy-Walker malformation was based on only two exposed cases. Conclusion These results should be interpreted cautiously because multiple statistical tests were conducted and measurements of exposure were based on maternal report. However, our results may be useful for generating hypotheses for future studies. Birth Defects Research (Part A) 106:563–572, 2016. © 2016 Wiley Periodicals, Inc. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text