Prospective and randomized clinical trial for the treatment of hepatocellular carcinoma ? a comparison of L-TAE with Farmorubicin and L-TAE with Adriamycin (second cooperative study)

Autor: Mitsuo Kusano, Yasuo Ohashi, Makoto Ogawa, Jushiro Inoue, Yu Sakata, Naofumi Nagasue, Takesada Mori, Kenichi Takayasu, Yoshifumi Kawarada, Toshitsugu Oda, Morito Monden, Y. Kubo, Akira Takahashi, Kazuo Tamura, Jun Okamura, Yoshimi Nakanishi, Manabu Masuzawa, Masayoshi Tani, Shuichi Mikuriya, Yasuhiro Yumoto, Yoshiyuki Shimamura, Saburo Kawai, Kenji Jinno, Masaoki Makino, Chikazumi Kuroda
Rok vydání: 1992
Předmět:
Zdroj: Cancer Chemotherapy and Pharmacology. 31:S20-S24
ISSN: 1432-0843
0344-5704
DOI: 10.1007/bf00687099
Popis: A randomized clinical trial comparing L-TAE with Farmorubicin (FARM) and L-TAE with Adriamycin (ADR) in the treatment of hepatocellular carcinoma was conducted from October 1989 through December 1990. In all, 192 hospitals participated in this study and 117 patients were entered. The patients were randomly allocated to group A (L-TAE+FARM) or group B (L-TAE+ADR). There was no significant intergroup difference in background factors. Additional treatment consisting of repeated TAE or surgery was given to 66 patients. Four factors were analyzed in this study: the percentage of reduction in tumor size, the change in the AFP level, lipiodol accumulation, and survival. None of these factors differed significantly between the two groups. The final evaluation of this study will be based on differences in survival after a long-term follow-up. Toxic effects manifested less frequently in group A than in group B, and the decrease in the platelet count in the peripheral blood was significantly lower in group A than in group B. These results suggest that FARM exerts a more favorable effect than does ADR in the treatment of hepatocellular carcinoma.
Databáze: OpenAIRE
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