Antioxidant effect of Zanthoxylum limonella Alston
| Autor: | Janpen Tangjitjaroenkun, Roongtawan Supabphol, Warinthorn Chavasiri |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Pharmacology
Antioxidant biology Traditional medicine DPPH medicine.medical_treatment Trolox equivalent antioxidant capacity Pharmaceutical Science Plant Science Glutathione biology.organism_classification law.invention Lipid peroxidation chemistry.chemical_compound Complementary and alternative medicine Zanthoxylum chemistry Biochemistry law Catalase Drug Discovery biology.protein medicine Essential oil |
| Zdroj: | Journal of Medicinal Plants Research. 6 |
| ISSN: | 1996-0875 |
| DOI: | 10.5897/jmpr10.846 |
| Popis: | Zanthoxylum limonella Alston. (Rutaceae) has been widely used as spice and folk medicine. Different part of this plant, such as ripe fruit was used as a condiment in curries, and its essential oil is quite useful for blood circulation and gastrointestinal tract. The bark was noted for its febrifugal, sudorific and diuretic properties. It has been used for treatment of fever caused by free radical production in the recticulo-endothelial system. The present work investigates the antioxidative potential of Z. limonella crude extracts and essential oil on cell-free and cell-based systems. 1,1-diphenyl-2-picrylhydrazyl (DPPH) and trolox equivalent antioxidant capacity (TEAC) assays showed the same ranking order of free radical scavenging activity, methanol extract of stems (SM) > dichloromethane extract of stems (SD) > essential oil of fruits (EO). However, leave extracts exhibited very low radical scavenging activity. Treatment with SD, SM, and EO significantly decreased the malondialdehyde (MDA) level of cell lysates obtained from pretreated prostate cancer cells, while glutathione (GSH) and catalase (CAT) levels increased. The result of the antioxidative potential of Z. limonella indicated that crude extracts, SD and SM, from stems and essential oil from fruits of Z. limonella exhibited the antioxidant activity possibly related to the regulation of CAT and GSH in prostate cancer cells. Key words: Zanthoxylum limonella Alston., antioxidant activity, 1,1-diphenyl-2-picrylhydrazyl (DPPH), trolox equivalent antioxidant capacity (TEAC), prostate cancer, lipid peroxidation, glutathione (GSH), catalase (CAT). |
| Databáze: | OpenAIRE |
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