Development of P22 Viral Capsid Nanocomposites as Anti-Cancer Drug, Bortezomib (BTZ), Delivery Nanoplatforms

Autor:	Hyojin Moon, Sung You Hong, Hyun-Hee Shin, Sebyung Kang, Hyun Ji Yang, Junseon Min
Rok vydání:	2014
Předmět:	chemistry.chemical_classification Nanocomposite Polymers and Plastics Bortezomib viruses Bioengineering Peptide Conjugated system Virology Biomaterials chemistry Capsid Drug delivery Anti cancer drugs Materials Chemistry medicine Cancer research Viability assay Biotechnology medicine.drug
Zdroj:	Macromolecular Bioscience. 14:557-564
ISSN:	1616-5187
Popis:	Genetic and chemical engineering approaches are used to employ P22 viral capsids as nanoplatforms for developing an efficient delivery vehicle. Catechol ligands are chemically attached to the interior surface of P22 viral capsid for subsequent encapsulation of an anticancer drug, bortezomib (BTZ), through boronic acid-diol complexation. For targeted delivery, hepatocellular carcinoma (HCC)-targeting peptide (SP94, SFSIIHTPILPL) is synthesized and chemically conjugated to the exterior surface of the P22 viral capsid nanocomposites. Effective targeted delivery of synthesized P22 viral capsid nanocomposites is demonstrated by fluorescent cell imaging and the efficacy of delivered P22 viral capsid nanocomposites is evaluated using a cell viability assay.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6c6949df0e1adc726120a298465eec73 https://doi.org/10.1002/mabi.201300401 Zobrazit plný text záznamu Plný text