Abstract 547: Glycocylated Hemoglobin Targets Among Diabetics and Cardiovascular Disease: Do We Need to Change Focus?
| Autor: | Ricky Patel, Chinelo Madubum, Raja Chand, Tanyka Sam, Kunal Nangrani, Ebenezer T Oni, Siva Buddhavarapu |
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| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Arteriosclerosis, Thrombosis, and Vascular Biology. 37 |
| ISSN: | 1524-4636 1079-5642 |
| Popis: | Background: Diabetes is an established risk factor for cardiovascular disease (CVD). Glycosylated hemoglobin (HbA1C) targets are surrogate markers to monitor disease progression and guide treatment. While HbA1C targets are relevant in ascertaining glycemic control, the relationship of the established cutoffs and cardiovascular disease risk are not clear. Methods: We conducted a step wise logistic regression from a cohort of 1,065 diabetic patients attending the Ambulatory Care Clinic at The Brooklyn Hospital Center between 2012- 2014. CAD was defined as a diagnosis of coronary artery disease in the health records. Results: Twelve percent were females, 9% of the individuals achieved an HbA1C target ≤ 7%., and 12% had a history of CAD. Thirty-eight percent were taking metformin, 18% were on insulin. Only 7% of individuals with CAD had their A1C at target. Both a linear regression of HbA1C and logistic regression of HbA1C > 7% did not show any significant association with CAD, See table 1. Conclusion: This cross-sectional analysis of diabetic patients on treatment did not show an association between glycosylated hemoglobin and CAD. It is therefore imperative for future studies to evaluate the relationship between HbA1C and cardiovascular outcomes and ascertain the usefulness of this marker to guide CVD treatment strategies in diabetics. Model 1-unadusted, Model 2- adjusted for BMI, Model 3- adjusted for BMI, LDL, HDL, gender, Metformin use, insulin use. |
| Databáze: | OpenAIRE |
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