Pulsatile Luteinizing Hormone Secretion in Patients with Addison’s Disease. Impact of Glucocorticoid Substitution1
| Autor: | Claus Hagen, Jørgen Hangaard, Ellen Grodum, O Koldkjaer, Marianne Andersen |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
endocrine system
medicine.medical_specialty Luteinizing hormone secretion medicine.drug_class business.industry Endocrinology Diabetes and Metabolism Biochemistry (medical) Clinical Biochemistry medicine.disease Biochemistry Endocrinology TRH stimulation test Internal medicine Addison's disease medicine Adrenal insufficiency Corticosteroid business Glucocorticoid medicine.drug Blood sampling Hydrocortisone |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 83:736-743 |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/jcem.83.3.4671 |
| Popis: | The physiological and pathophysiological role of cortisol in pulsatile LH release was investigated in 14 patients (5 men, 6 premenopausal women, and 3 postmenopausal women) with Addison’s disease. The explicit effect of cortisol in relation to the effect of corticotropin-releasing factor (CRF), ACTH, and opioids was ensured by hypo-, normo-, and hypercortisolism. Hypocortisolism was obtained by 24-h discontinuation of hydrocortisone (HC) followed by 23-h saline infusion. Eucortisolism was secured by infusion of HC (0.5 mg/kg) over 23 h. Stress-appropriate hypercortisolism was obtained by infusion of HC (2.0 mg/kg) over 23 h, preceded by treatment for 5 days with dexamethasone (1.5 mg/day). To imitate the normal diurnal rhythm for serum cortisol, HC was infused in graduated doses. Blood sampling was performed every 10 min during the last 10 h of the study period, followed by a LH-releasing hormone test (5 μg, iv) and a TRH test (10μ g, iv). In pre- and postmenopausal women, the mean LH level and the LH pul... |
| Databáze: | OpenAIRE |
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