Relationship between cognitive and immune functioning in children born to HIV‐1 seropositive women
| Autor: | Bruce K. Christensen, Rolando R. Henry, Ellen Moore, Flossie Cohen, Juliet M. Coscia |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pediatrics
medicine.medical_specialty Pregnancy Offspring virus diseases medicine.disease Bayley Scales of Infant Development Cognitive test Developmental psychology Neuropsychology and Physiological Psychology Acquired immunodeficiency syndrome (AIDS) Immunopathology Developmental and Educational Psychology medicine Serostatus Psychology Psychosocial |
| Zdroj: | Developmental Neuropsychology. 12:283-298 |
| ISSN: | 1532-6942 8756-5641 |
| Popis: | This study examined the relative contributions of immune system dysfunction, HIV type 1 (HIV‐1) serostatus, and psychosocial and environmental cofactors to cognitive functioning in children (N=46), ages 1 year 3 months to 9 years 3 months. All children were born to HIV‐1 seropositive women; children's cord blood at birth was positive for HIV‐1 antibodies. However, subsequent testing for HIV‐1 antibodies at age 1 year 3 months revealed that 54% of the sample were HIV‐1 infected while 46%, although exposed to HIV‐1 in utero, were uninfected. Children were administered the Bayley Scales of Infant Development or McCarthy Scales of Children's Abilities to assess level of overall cognitive functioning. Immune system dysfunction was indexed by the percent of CD4+ cells proximal to time of cognitive testing. Psychosocial and environmental cofactors included offspring demographic characteristics (age, gender, ethnicity), caregiver status, and maternal drug use during pregnancy. Multiple hierarchical regression ana... |
| Databáze: | OpenAIRE |
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