| Autor: |
Kazu Okuma, Ken Maeda, Shuetsu Fukushi, Tsuguto Fujimoto, Takashi Sato, Keita Ishijima, Tadaki Suzuki, Hitomi Kinoshita, Makoto Ohnishi, Souichi Yamada, Kiyoko Nojima, Takayuki Kanno, Masanori Isogawa, Masaharu Shinkai, Minoru Tobiume, Ayae Nishiyama, Keisuke Tonouchi, Natsuo Tachikawa, Taishi Onodera, Ai Kawana-Tachikawa, Lin Sun, Kazutaka Terahara, Takayuki Matsumura, Tomohiro Takano, Saya Moriayma, Shigeki Nakamura, Takahiro Okai, Tetsuro Matano, Park Eunsil, Yudai Kuroda, Yoshimasa Takahashi, Takaji Wakita, Yu Adachi |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
SSRN Electronic Journal. |
| ISSN: |
1556-5068 |
| DOI: |
10.2139/ssrn.3831465 |
| Popis: |
SARS-CoV-2 variants have raised concerns regarding resistance to neutralizing antibodies elicited by the parental virus. In the present study, we monitored multiple parameters of neutralizing antibodies in convalescent plasma up to 10 months after the symptom onset. In contrast to marked decline of neutralizing antibody titers, the neutralization potency per antibody increased with time. The antigenic drift of B.1.351 (501Y.V2) and P.1 (501Y.V3) variants conferred resistance to neutralization by convalescent plasma in the early phase; however, the resistance of these variants was attenuated by progressive increase of neutralization potency and breadth over time. Furthermore, this increase in the neutralization potency/breadth were highly correlated with the affinity maturation of IgG antibodies that target virus conserved sites with extended half-lives. Despite a quantitative decline in the neutralizing antibody titers, the serological immunity shapes the neutralization potency and breadth with time, thereby acquiring persistent neutralizing activity toward SARS-CoV-2 variants. Declaration of Interest: All authors declare that they have no competing interests. Ethical Approval: All studies were approved by the Institutional Review Board of the National Institute of Infectious Diseases (#1127, #1132, and #1197). This study was performed in accordance with the Declaration of Helsinki. All volunteers provided written informed consent prior to enrollment. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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