Sensing and actuating electrophysiological activity on brain tissue and neuronal cultures with a high-density CMOS-MEA

Autor: Mauro Gandolfo, Luca Berdondini, Enrico Ferrea, K. Imfeld, Alessandro Maccione, Evelyne Sernagor, Alessandro Simi, Thierry Nieus
Rok vydání: 2013
Předmět:
Zdroj: 2013 Transducers & Eurosensors XXVII: The 17th International Conference on Solid-State Sensors, Actuators and Microsystems (TRANSDUCERS & EUROSENSORS XXVII).
Popis: Multielectrode arrays (MEAs) for electrophysiological studies in neuroscience can nowadays be realized with Complementary Metal Oxide Semiconductor (CMOS) technology to provide large active areas with several thousands of simultaneously recording microelectrodes and electrode densities with inter-electrode separations approaching cellular sizes. This provides spatial and temporal resolutions to literally image electrophysiological activity propagations. Here, we focus on the achieved sensing capabilities of a 64×64 electrode array as well as on the actuation performances of a novel CMOS-chip integrating 16 electrodes for electrical stimulation. We report and discuss our recent results obtained from neuronal cell cultures, brain slices and mouse retina preparations.
Databáze: OpenAIRE