CD4+ T-Cell Depression is Linked to the Severity of COVID-19 and Predicts Mortality

Autor: Esma Eryilmaz-Eren, Mustafa Yavuz Koker, Aysegul Ulu-Kilic, Hatice Tuna Hurmet-Oz, Yasemin Ay Altintop, Esma Saatci, Sevil Ozsoy, Aysin Kilinc-Toker, Ulas Serkan Topaloglu, Recep Civan Yuksel, Huseyin Avcilar, Zehra Bestepe-Dursun, Ilhami Celik
Rok vydání: 2023
Předmět:
Zdroj: Infectious Diseases and Clinical Microbiology. 5:21-30
ISSN: 2667-646X
DOI: 10.36519/idcm.2023.190
Popis: Objective: Most patients with coronavirus disease (COVID-19) have abnormalities of lymphocyte subsets. This study aimed to determine the distribution of lymphocytes in patients with various severity levels of COVID-19 and to describe the relationship between the CD4+ T helper and prognosis. Materials and Methods: Adult (>18 years old) patients with COVID-19 who followed up in a tertiary hospital were included in the study prospectively. Demographic and clinical characteristics of the patients were obtained from the hospital records. Peripheral flow cytometry was studied in patients with different severity of COVID-19 and different prognoses. Next, we analyzed the characteristics and predictive values of lymphocyte subsets in COVID-19 patients. Results: Totally 86 patients were included in the study, of which 21 (24.4%) had asymptomatic, 23 (26.7%) had mild/moderate, and 42 (48.8%) had severe/critical COVID-19. Severe/critical patients had lower lymphocyte levels and older age than asymptomatic patients (p
Databáze: OpenAIRE