Antibacterial Activity and DNA Binding Properties of Bivalent Metal Complexes of Cuminaldehyde Acetoylhydrazone
| Autor: | D. Dhanalakshmi, K. Srinivasulu, Y.B. Nagamani, K. Anuja, K. Hussain Reddy |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
chemistry.chemical_classification
Chemistry Supramolecular chemistry General Chemistry Biochemistry Combinatorial chemistry Bivalent (genetics) Coordination complex Metal chemistry.chemical_compound GEOBASE visual_art Drug Discovery visual_art.visual_art_medium Environmental Chemistry Cuminaldehyde Antibacterial activity DNA |
| Zdroj: | Oriental Journal Of Chemistry. 37:1125-1131 |
| ISSN: | 2231-5039 0970-020X |
| Popis: | Metallo-hydrazones having the formula [M(IBAH)2] (where, M = Ni(II), Cu(II) and Zn(II); IBAH = p-Isopropylbenzaldehyde acetoylhydrazone) are prepared and confirmed on the basis of physico-chemical and spectral analyses. Conductivity data revealed that the complexes are non-electrolytes. Metal-DNA interactions are investigated using absorption spectrophotometry. Binding constant (Kb) data revealed that the copper complex interact DNA more strongly than other complexes. Antibacterial activity studies indicated higher activity for complexes than the metal free hydrazone ligand. The copper compound displays higher activity. DNA binding constants are correlated with the activity of metal compounds in this article. |
| Databáze: | OpenAIRE |
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