Clinical study of low-dose weekly methotrexate for uncontrolled rheumadoid arthritis

Autor:	Sunao Morita, Kotaro Ohashi, Kiyotsugu Maekawa, Hideaki Uchigashima, Keiichiro Okajima
Rok vydání:	1990
Předmět:	musculoskeletal diseases Base line medicine.medical_specialty business.industry Low dose Arthritis Normal level medicine.disease Gastroenterology Surgery Clinical study Internal medicine Rheumatoid arthritis medicine Methotrexate business medicine.drug
Zdroj:	Orthopedics & Traumatology. 39:89-92
ISSN:	1349-4333 0037-1033
DOI:	10.5035/nishiseisai.39.89
Popis:	Five uncontrolled rheumatoid arthritis patients were treated with low-dose weekly methotrexate as part of the drug. A significant improvement from base line in all patients was recogized. In clinical paramters tested, ESR, CRP, grip power, and joint scores were improved, but RA and mornig stiffness were not distinctly improved during the short study (6-12 months). Also, predonine dose was decreased in all cases. An elevation of the transamylase value to 3 times the normal level forced us to withhold MTX treatment from two cases. In one case, the drug was restarted at the same dosage after this value returned to normal, and in the other case this treatment was given up for her apprehension.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::6c3c514a383692c177f40d8e07c8b2aa https://doi.org/10.5035/nishiseisai.39.89 Zobrazit plný text záznamu