The effects of soy protein containing phytoestrogens on menopausal symptoms in postmenopausal women
| Autor: | Fabien S Dalais, Yu-Lu Liang, Dimitra Kotsopoulos, Helena J. Teede, Barry P McGrath |
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| Rok vydání: | 2000 |
| Předmět: |
endocrine system
medicine.medical_specialty business.industry Daidzein food and beverages Obstetrics and Gynecology Genistein Physiology General Medicine Glycitein Isoflavones medicine.disease Placebo Menopause chemistry.chemical_compound Endocrinology chemistry Internal medicine medicine Phytoestrogens business Soy protein |
| Zdroj: | Climacteric. 3:161-167 |
| ISSN: | 1473-0804 1369-7137 |
| DOI: | 10.1080/13697130008500108 |
| Popis: | Objective To analyze the impact of soy protein dietary supplements containing phytoestrogens on menopausal symptoms in healthy postmenopausal women.Methods A double-blind, placebo-controlled trial was conducted in 94 healthy postmenopausal women aged 50–75 years, with 44 randomized to soy supplements containing 118 mg of isoflavones (daidzein, genistein, glycitein and their respective glycosides), and 50 to an identically presented casein placebo. A validated questionnaire on menopausal symptoms was administered at baseline and at 3 months of treatment. Compliance was assessed by high-performance liquid chromatography assay of urinary phytoestrogens. Statistical analysis was completed using non-parametric statistical methods and multivariate analysis.Results At baseline 80% of women recruited were experiencing menopausal symptoms, although symptom severity was mild. Those consuming phytoestrogen supplements had 13- and 17-fold increases in urinary excretion of genistein and daidzein, respectively, with no... |
| Databáze: | OpenAIRE |
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