A normoglykaemia elérésének korlátai inzulinkezelt 2-es típusú cukorbetegekben

Autor:	Beatrix Domján, László Gerő, Viktória Ferencz, Tímea Tänczer, Gy. Ádám Tabák
Rok vydání:	2015
Předmět:	medicine.medical_specialty business.industry Insulin medicine.medical_treatment General Medicine Disease Evidence-based medicine Hypoglycemia medicine.disease Lower risk Endocrinology Pharmacokinetics Internal medicine Diabetes mellitus medicine medicine.symptom business Weight gain
Zdroj:	Orvosi Hetilap. 156:1443-1450
ISSN:	1788-6120 0030-6002
DOI:	10.1556/650.2015.30239
Popis:	Insulin therapy is the most effective treatment of diabetes. It is proven to prevent microvascular disease and likely to decrease the risk of cardiovascular complications. However, these benefits are associated with a 2-3 times increased risk of hypoglycaemia and a faster weight gain compared to other antidiabetic medications. In addition, one study found elevated all-cause mortality among patients on intensive therapy (requiring more frequent insulinisation). Insulin has growth factor properties that may translate to increased mitogenicity. These factors could prevent the medical team or the patient from initiation or intensification of insulin therapy. The authors describe evidence on long-term remission related to transient intensified insulin therapy at diabetes diagnosis. The currently recommended method of insulin initiation is once daily basal insulin treatment that offers different schedules for intensification. The authors review the pharmacokinetics of analogue insulins that translate to similar efficacy to human insulins with a 20-30% lower risk of hypoglycaemia. Orv. Hetil., 2015, 156(36), 1443–1450.
Databáze:	OpenAIRE
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