Putaminal Diffusivity Correlates With Disease Progression in Parkinson's Disease
| Autor: | Helmut Rumpel, Kia-Min Ng, Chooi-Sum Yeoh, Ling Ling Chan, Huihua Li, Eng-King Tan |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Pathology
medicine.medical_specialty Longitudinal study Parkinson's disease business.industry Putamen Substantia nigra General Medicine medicine.disease 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine nervous system Cohort Medicine Biomarker (medicine) business Nuclear medicine Prospective cohort study 030217 neurology & neurosurgery Diffusion MRI |
| Zdroj: | Medicine. 95:e2594 |
| ISSN: | 0025-7974 |
| Popis: | Diffusion tensor imaging (DTI) is an increasingly used noninvasive imaging tool. However its long-term clinical utility is unclear. Parkinson's disease (PD) is a common neurodegenerative disease. We prospectively examined a cohort of 46 Parkinson's disease (PD) patients who underwent diffusion tensor imaging (DTI) of the brain at baseline and 6 years later on a 1.5 Tesla scanner using a standardized protocol. DTI parameters of mean diffusivity (MD) and fractional anisotrophy (FA) were extracted using regions-of-interest (ROIs) analysis from various brain regions. Compared to the baseline scan, MD increased in all brain regions (P |
| Databáze: | OpenAIRE |
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