ORIGINAL ARTICLE: Selective Downregulation of Phosphoinositide 3-Kinase alpha in Leukocytes During Pregnancy
| Autor: | Udo R. Markert, Tobias G. Poehlmann, Ignacio Rubio, Michael Gruen, Anne Rohrbach, Mehtab Bulgay-Moerschel, Christian Koenig |
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| Rok vydání: | 2009 |
| Předmět: |
medicine.medical_specialty
Phosphoinositide 3-kinase biology Immunology Obstetrics and Gynecology P110α Blot Endocrinology Immune system Reproductive Medicine Downregulation and upregulation Internal medicine medicine biology.protein Immunology and Allergy Signal transduction Receptor PI3K/AKT/mTOR pathway |
| Zdroj: | American Journal of Reproductive Immunology. 61:130-135 |
| ISSN: | 1046-7408 |
| DOI: | 10.1111/j.1600-0897.2008.00672.x |
| Popis: | Problem During pregnancy, it is crucially important that the mother’s immune system tolerates the developing embryo. Although a number of mechanisms of immunological tolerance have been described, little is known about intracellular signaling events, causing a decrease in the mother’s leukocyte activity. Method of study We investigated the expression and activity of phosphoinositide 3-kinases (PI3K) in maternal blood cells of healthy volunteers by Reverse Transcription PCR and Western blotting. Results Our data reveal a selective downregulation of the p110α catalytic isoform. This correlated with a slight decrease in PI3K activity as judged by the levels of phosphorylated Akt. Conclusion As PI3K are involved in signal transduction of various leukocyte receptors, this downregulation may comprise a means of holding immune functions at bay. |
| Databáze: | OpenAIRE |
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