Evaluation of patients with advanced epithelial ovarian cancer before primary treatment: correlation between tumour burden assessed by [18F]FDG PET/CT volumetric parameters and tumour markers HE4 and CA125

Autor: Pere Fusté, Berta Díaz-Feijoo, Nuria Carreras-Dieguez, David Fuster, Inmaculada Romero, Marta del Pino, Pilar Paredes, E Gonzalez-Bosquet, Lydia Gaba, Esther Fernández-Galán, Aureli Torné, Ariel Glickman, Jaume Pahisa, N. Sánchez-Izquierdo, Blanca Gil-Ibáñez, Josep L. Carrasco, Andrés Perissinotti, Núria Agustí, Aida Niñerola-Baizán
Rok vydání: 2021
Předmět:
Zdroj: European Radiology. 32:2200-2208
ISSN: 1432-1084
0938-7994
DOI: 10.1007/s00330-021-08305-x
Popis: Accurate assessment of disease extent is required to select the best primary treatment for advanced epithelial ovarian cancer patients. Estimation of tumour burden is challenging and it is usually performed by means of a surgical procedure. Imaging techniques and tumour markers can help to estimate tumour burden non-invasively. 2-[18F]FDG PET/CT allows the evaluation of the whole-body disease. This study aimed to correlate HE4 and CA125 serum concentrations with tumour burden evaluated by volumetric 2-[18F]FDG PET/CT parameters in advanced high-grade epithelial ovarian cancer. We included 66 patients who underwent 2-[18F]FDG PET/CT and serum tumour markers determination before primary treatment. Volumes of interest were delimited in every pathological uptake. Whole-body metabolic tumour volume (wb_MTV) and total lesion glycolysis (wb_TLG) were calculated summing up every VOI’s MTV value. SUVmax thresholds were set at 40% (MTV40 and TLG40) and 50% (MTV50 and TLG50). In addition, four VOI subgroups were defined: peritoneal carcinomatosis, retroperitoneal nodes, supradiaphragmatic nodes, and distant metastases. MTV and TLG were calculated for each group by adding up the corresponding MTV values. TLG was calculated likewise. wb_MTV and wb_TLG were found to be significantly correlated with serum CA125 and HE4 concentrations. The strongest correlation was observed between HE4 and wb_MTV40 (r = 0.62, p
Databáze: OpenAIRE
Externí odkaz: