Development of highly porous biodegradable γ-Fe2O3/polyvinyl alcohol nanofiber mats using electrospinning process for biomedical application
| Autor: | Noordin Mohd Yusof, Ani Idris, Effaliza Misran, Nor Hasrul Akhmal Ngadiman, Denni Kurniawan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Materials science
Biocompatibility Nanoparticle Bioengineering Nanotechnology 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Polyvinyl alcohol Electrospinning 0104 chemical sciences Biomaterials Contact angle chemistry.chemical_compound chemistry Mechanics of Materials Nanofiber Composite material 0210 nano-technology Porosity Spinning |
| Zdroj: | Materials Science and Engineering: C. 70:520-534 |
| ISSN: | 0928-4931 |
| DOI: | 10.1016/j.msec.2016.09.002 |
| Popis: | The use of electrospinning process in fabricating tissue engineering scaffolds has received great attention in recent years due to its simplicity. The nanofibers produced via electrospinning possessed morphological characteristics similar to extracellular matrix of most tissue components. Porosity plays a vital role in developing tissue engineering scaffolds because it influences the biocompatibility performance of the scaffolds. In this study, maghemite (γ-Fe2O3) was mixed with polyvinyl alcohol (PVA) and subsequently electrospun to produce nanofibers. Five factors; nanoparticles content, voltage, flow rate, spinning distance, and rotating speed were varied to produce the electrospun nanofibrous mats with high porosity value. Empirical model was developed using response surface methodology to analyze the effect of these factors to the porosity. The results revealed that the optimum porosity (90.85%) was obtained using 5% w/v nanoparticle content, 35 kV of voltage, 1.1 ml/h volume flow rate of solution, 8 cm spinning distance and 2455 rpm of rotating speed. The empirical model was verified successfully by performing confirmation experiments. The properties of optimum PVA/γ-Fe2O3 nanofiber mats such as fiber diameter, mechanical properties, and contact angle were investigated. In addition, cytocompatibility test, in vitro degradation rate, and MTT assay were also performed. Results revealed that high porosity biodegradable γ-Fe2O3/polyvinyl alcohol nanofiber mats have low mechanical properties but good degradation rates and cytocompatibility properties. Thus, they are suitable for low load bearing biomedical application or soft tissue engineering scaffold. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect