Disfunción endotelial como alteración primaria en las patologías vasculares
| Autor: | Cuevas A, Faúndez L, Germain A, Valdés G, Irribarra |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
medicine.medical_specialty
Vascular smooth muscle Endothelium business.industry Stimulation Vasodilation General Medicine medicine.disease Nitric oxide chemistry.chemical_compound Endocrinology medicine.anatomical_structure chemistry Internal medicine medicine Endothelial dysfunction business Acetylcholine medicine.drug Artery |
| Zdroj: | Revista médica de Chile. 128 |
| ISSN: | 0034-9887 |
| DOI: | 10.4067/s0034-98872000000600014 |
| Popis: | Endothelium controls vascular smooth muscle tone by secreting relaxing and contracting factors. There is a constant release of endothelium derived relaxing factors, mainly nitric oxide, a potent vasodilator, inhibitor of platelet aggregation, monocyte adhesion and smooth muscle proliferation. In addition, the endothelium may increase the release of NO in response to humoral stimulation by vasoactive substances such as acetylcholine, bradikinin or substance P. Although the endothelium releases a number of products, no single blood test has yet proved useful to determine normal endothelial function or as early abnormalities. The most useful test of endothelial function relies on the meassurement of endothelium-dependent dilatation in response to pharmacological or physiologic stimuli. The alteration of this response is known as endothelial dysfunction and has been observed in a variety of circumstances related to cardiovascular risk. This review summarizes the evidence that sustains this association and emphasizes the clinical utility of assessing endothelial function presenting two clinical cases of hypercholesterolemia in which a high-resolution vascular ultrasound in the braquial artery was used. (Rev Med Chile 2000; 128: 659-70). |
| Databáze: | OpenAIRE |
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